The 6th International Conference on Frontiers in Computing and Systems (COMSYS-2025) will be held from September 25-27, 2025, at the Faculty of Mathematics and Information Science, Warsaw University of Technology, Warsaw, Poland, jointly organized by the Warsaw University of Technology, Poland, and COMSYS Educational Trust, Kolkata, India. Centered around the theme "Artificial Intelligence, Bioinformatics, Computational Genomics," COMSYS-2025 aims to bring together researchers, academicians, and industry professionals to discuss the latest advancements in Computational Genomics, Bioinformatics, and Biomedical Informatics; Artificial Intelligence, Machine Learning, and Data Science; and Communication Networks, Cloud Computing, Security, and IoT. This conference serves as a vibrant platform for interdisciplinary collaboration, providing opportunities for high-quality research presentations, networking with global experts, and discussions on innovative solutions to contemporary challenges in computing and system sciences. By uniting academia and industry, COMSYS-2025 fosters cutting-edge research and fosters meaningful collaborations to drive technological advancements. We invite researchers, professionals, and students to participate in COMSYS-2025 and contribute to the future of computing and system sciences.